Naturally fuelled by curiosity . . .
Scientific PUBLICATIONS
“Nothing in life is to be feared,
it is only to be understood.
Now is the time to understand more,
so that we may fear less.”
- Marie Skłodowska Curie -
20. An experimental target-based platform in yeast for screening Plasmodium vivax deoxyhypusine synthase inhibitors.
Fernandes Silva S, Hollunder Klippel A, Sigurdardóttir S, Mahdizadeh SJ, Tiukova I, Bourgard C, Salazar-Alvarez LC, do Amaral Prado HM, de Araujo RV, Costa FTM, Bilsland E, King RD, Brauer Massirer K, Eriksson LA, Bengtson MH, Zanelli CF, Sunnerhagen P. PLoS Negl Trop Dis. 2024 Dec 2;18(12):e0012690. doi: 10.1371/journal.pntd.0012690. eCollection 2024 Dec. PMID: 39621767 Free PMC article.
Andrade C, Sousa BKP, Sigurdardóttir S, Bourgard C, Borba J, Clementino L, Salazar-Alvarez LC, Groustra S, Zigweid R, Khim M, Staker B, Costa F, Eriksson L, Sunnerhagen P. Res Sq [Preprint]. 2024 Feb 20:rs.3.rs-3963523. doi: 10.21203/rs.3.rs-3963523/v1. PMID: 38463971 Free PMC article. Preprint.
Tomaz KCP, Tavella TA, Borba JVB, Salazar-Alvarez LC, Levandoski JE, Mottin M, Sousa BKP, Moreira-Filho JT, Almeida VM, Clementino LC, Bourgard C, Massirer KB, Couñago RM, Andrade CH, Sunnerhagen P, Bilsland E, Cassiano GC, Costa FTM. Antimicrob Agents Chemother. 2023 Oct 11:e0058923. doi: 10.1128/aac.00589-23. Online ahead of print. PMID: 37819090
17. Benzo[b]naphtho[2,1-d]furans and 2-Phenylnaphthalenes from Streblus usambarensis.
Chepkirui C, Ali Adem F, Rudenko A, Gütlin Y, Ndakala A, Derese S, Orthaber A, Bourgard C, Yenesew A, Erdélyi M.J Nat Prod. 2023 Apr 28;86(4):1010-1018. doi: 10.1021/acs.jnatprod.3c00051. Epub 2023 Apr 12.PMID: 37043719
16. Macrocyclic Pyrrolizidine Alkaloids and Silphiperfolanol Angelate Esters from Solanecio mannii.
Umereweneza D, Atilaw Y, Peintner S, Rudenko A, Bourgard C, Xiong R, Muhizi T, Sunnerhagen P, Gogoll A, Erdelyi M. EurJOC. 2023 Jan 12. doi: 10.1002/ejoc.202201280.
15. Development of Dicationic Bisguanidine-Arylfuran Derivatives as Potent Agents against Gram-Negative Bacteria.
Bourgard C, Rodríguez-Hernández D, Rudenko A, Rutgersson C, Palm M, Larsson DGJ, Farewell A, Grøtli M, Sunnerhagen P. Antibiotics (Basel). 2022 Aug 17;11(8):1115. doi: 10.3390/antibiotics11081115. PMID: 36009984
14. Polyoxygenated cyclohexene derivatives and flavonoids from the leaves of Uvaria pandensis.
Maeda G, Gilissen PJ, Bourgard C, van der Wal J, Munissi JJE, Nyandoro SS, Erdélyi M. Fitoterapia. 2022 Mar 11:105170. doi: 10.1016/j.fitote.2022.105170. Online ahead of print. PMID: 35288209
13. A new ß-hydroxydihydrochalcone from Tephrosia uniflora, and the revision of three ß-hydroxydihydrochalcones to flavanones.
Chepkirui C, Bourgard C, Gilisen PJ, Ndakala A, Derese S, Gütlin Y, Erdélyi M, Yenesew A. Fitoterapia. 2022 Feb 24:105166. doi: 10.1016/j.fitote.2022.105166. Online ahead of print. PMID: 35219716
12. A Genetic Trap in Yeast for Inhibitors of SARS-CoV-2 Main Protease.
Alalam H, Sigurdardóttir S, Bourgard C, Tiukova I, King RD, Grøtli M, Sunnerhagen P. mSystems. 2021 Nov 23:e0108721. doi: 10.1128/mSystems.01087-21. Online ahead of print. PMID: 34812651
11. Oxygenated Cyclohexene Derivatives from the Stem and Root Barks of Uvaria pandensis.
Maeda G, Gilissen PJ, Rudenko A, van der Wal J, Bourgard C, Gupta AK, Sunnerhagen P, Munissi JJE, Nyandoro SS, Erdélyi M. J Nat Prod. 2021 Nov 21. doi: 10.1021/acs.jnatprod.1c00811. Online ahead of print. PMID: 34802242
10. A suitable RNA preparation methodology for whole transcriptome shotgun sequencing harvested from Plasmodium vivax-infected patients.
Bourgard C, Lopes SCP, Lacerda MVG, Albrecht L, Costa FTM. Sci Rep. 2021 Mar 3;11(1):5089. doi: 10.1038/s41598-021-84607-w. PMID: 33658571
9. Antibacterial and cytotoxic biflavonoids from the root bark of Ochna kirkii.
Kalenga TM, Ndoile MM, Atilaw Y, Munissi JJE, Gilissen PJ, Rudenko A, Bourgard C, Sunnerhagen P, Nyandoro SS, Erdelyi M. Fitoterapia. 2021 Feb 11:104857. doi: 10.1016/j.fitote.2021.104857. Online ahead of print. PMID: 33582268
8. Biflavanones, Chalconoids, and Flavonoid Analogues from the Stem Bark of Ochna holstii.
Kalenga TM, Ndoile MM, Atilaw Y, Gilissen PJ, Munissi JJE, Rudenko A, Bourgard C, Sunnerhagen P, Nyandoro SS, Erdelyi M. J Nat Prod. 2021 Jan 29. doi: 10.1021/acs.jnatprod.0c01017. Online ahead of print. PMID: 33511842
7. Antibacterial and cytotoxic prenylated dihydrochalcones from Eriosema montanum.
Umereweneza D, Atilaw Y, Rudenko A, Gütlin Y, Bourgard C, Gupta AK, Orthaber A, Muhizi T, Sunnerhagen P, Erdélyi M, Gogoll A. Fitoterapia. 2021 Jan 11;149:104809. doi: 10.1016/j.fitote.2020.104809. Online ahead of print. PMID: 33359421 Free article.
6. Rosettes integrity protects Plasmodium vivax of being phagocytized.
Albrecht L, Lopes SCP, da Silva ABIE, Barbosa V, Almeida RP, Siqueira AM, Leite JA, Bittencourt NC, Dos Santos HG, Bourgard C, Garcia LFC, Kayano ACAV, Soares IS, Russell B, Rénia L, Lacerda MVG, Costa FTM. Sci Rep. 2020 Oct 7;10(1):16706. doi: 10.1038/s41598-020-73713-w. PMID: 33028898 Free PMC article.
5. Genetic sequence characterization and naturally acquired immune response to Plasmodium vivax Rhoptry Neck Protein 2 (PvRON2).
Bittencourt NC, Leite JA, Silva ABIE, Pimenta TS, Silva-Filho JL, Cassiano GC, Lopes SCP, Dos-Santos JCK, Bourgard C, Nakaya HI, da Silva Ventura AMR, Lacerda MVG, Ferreira MU, Machado RLD, Albrecht L, Costa FTM. Malar J. 2018 Oct 31;17(1):401. doi: 10.1186/s12936-018-2543-7. PMID: 30382855 Free PMC article.
4. Plasmodium vivax Biology: Insights Provided by Genomics, Transcriptomics and Proteomics.
Bourgard C, Albrecht L, Kayano ACAV, Sunnerhagen P, Costa FTM. Front Cell Infect Microbiol. 2018 Feb 8;8:34. doi: 10.3389/fcimb.2018.00034. eCollection 2018. PMID: 29473024 Free PMC article. Review.
3. MicroRNAs in the Host-Apicomplexan Parasites Interactions: A Review of Immunopathological Aspects.
Judice CC, Bourgard C, Kayano AC, Albrecht L, Costa FT. Front Cell Infect Microbiol. 2016 Feb 2;6:5. doi: 10.3389/fcimb.2016.00005. eCollection 2016. PMID: 26870701 Free PMC article. Review.
2. Potential for adaptation overrides cost of resistance.
Moura de Sousa J, Sousa A, Bourgard C, Gordo I. Future Microbiol. 2015;10(9):1415-31. doi: 10.2217/fmb.15.61. Epub 2015 Sep 7. PMID: 26343510 Free PMC article.
1. Rates of transposition in Escherichia coli.
Sousa A, Bourgard C, Wahl LM, Gordo I. Biol Lett. 2013 Dec 4;9(6):20130838. doi: 10.1098/rsbl.2013.0838. Print 2013. PMID: 24307531 Free PMC article.
Biflavanones, Chalconoids, and Flavonoid Analogues from the Stem Bark of Ochna holstii.
Kalenga TM, Ndoile MM, Atilaw Y, Gilissen PJ, Munissi JJE, Rudenko A, Bourgard C, Sunnerhagen P, Nyandoro SS, Erdelyi M. J Nat Prod. 2021 Jan 29. doi: 10.1021/acs.jnatprod.0c01017. Online ahead of print.PMID: 33511842
Antibacterial and cytotoxic prenylated dihydrochalcones from Eriosema montanum.
Umereweneza D, Atilaw Y, Rudenko A, Gütlin Y, Bourgard C, Gupta AK, Orthaber A, Muhizi T, Sunnerhagen P, Erdélyi M, Gogoll A. Fitoterapia. 2021 Jan 11;149:104809. doi: 10.1016/j.fitote.2020.104809. Online ahead of print.PMID: 33359421 Free article.
Rosettes integrity protects Plasmodium vivax of being phagocytized.
Albrecht L, Lopes SCP, da Silva ABIE, Barbosa V, Almeida RP, Siqueira AM, Leite JA, Bittencourt NC, Dos Santos HG, Bourgard C, Garcia LFC, Kayano ACAV, Soares IS, Russell B, Rénia L, Lacerda MVG, Costa FTM. Sci Rep. 2020 Oct 7;10(1):16706. doi: 10.1038/s41598-020-73713-w.PMID: 33028898 Free PMC article.
Bittencourt NC, Leite JA, Silva ABIE, Pimenta TS, Silva-Filho JL, Cassiano GC, Lopes SCP, Dos-Santos JCK, Bourgard C, Nakaya HI, da Silva Ventura AMR, Lacerda MVG, Ferreira MU, Machado RLD, Albrecht L, Costa FTM. Malar J. 2018 Oct 31;17(1):401. doi: 10.1186/s12936-018-2543-7.PMID: 30382855 Free PMC article.
Plasmodium vivax Biology: Insights Provided by Genomics, Transcriptomics and Proteomics.
Bourgard C, Albrecht L, Kayano ACAV, Sunnerhagen P, Costa FTM. Front Cell Infect Microbiol. 2018 Feb 8;8:34. doi: 10.3389/fcimb.2018.00034. eCollection 2018.PMID: 29473024 Free PMC article. Review.
MicroRNAs in the Host-Apicomplexan Parasites Interactions: A Review of Immunopathological Aspects.
Judice CC, Bourgard C, Kayano AC, Albrecht L, Costa FT. Front Cell Infect Microbiol. 2016 Feb 2;6:5. doi: 10.3389/fcimb.2016.00005. eCollection 2016.PMID: 26870701 Free PMC article. Review.
Potential for adaptation overrides cost of resistance.
Moura de Sousa J, Sousa A, Bourgard C, Gordo I. Future Microbiol. 2015;10(9):1415-31. doi: 10.2217/fmb.15.61. Epub 2015 Sep 7.PMID: 26343510 Free PMC article.
Rates of transposition in Escherichia coli.
Sousa A, Bourgard C, Wahl LM, Gordo I. Biol Lett. 2013 Dec 4;9(6):20130838. doi: 10.1098/rsbl.2013.0838. Print 2013.PMID: 24307531 Free PMC article.
PRESENTATION - Bourgard C "A suitable RNA preparation methodology for whole transcriptome shotgun sequencing harvested from Plasmodium vivax‑infected patients" at 8th International Conference on Plasmodium vivax Research, from 5th to 8th April 2022, Global Virtual Event
POSTER - Bourgard C and Sunnerhagen P. "An Implementation of In-silico Molecular Target Identification for Yeast Target-based Screening: Rational Design for Antimicrobial Drug Discovery" at EMBL Conference on Target Validation Using Genomics and Informatics, from 8th to 10th December 2019, Heidelberg - GERMANY
POSTER - Bourgard C, Reymer A, Gao C, Ashok A, Deplace V, Barbier M, Eriksson L, Grøtli M, Witkowski B, Costa FTM, Bilsland E and Sunnerhagen P. “Coupling Yeast Surrogate Genetics and in silico Modelling and Virtual Ligand Screening for Target-based Drug Discovery: the neglected vivax malaria case” at 9th Brazilian Symposium of Medicinal Chemistry, from 1st to 4th September 2019, Pirenópolis, Goiás - BRAZIL
POSTER - Bourgard C, Reymer A, Gao C, Ashok A, Deleplace V, Barbier M, Eriksson LA, Grøtli M, Witkowski B, Costa FTM, Bilsland E and Sunnerhagen P. "The Neglected Vivax Malaria Case: coupling Plasmodium spp. and Humanized Yeast Surrogate Genetics with In Silico Modelling for Target-based Drug Discovery" at XXIX International Conference on Yeast Genetics and Molecular Biology, from 18th to 22th August 2019, Gothenburg - SWEDEN
POSTER - Bourgard C, Lopes SCV, Lacerda MVG, Sunnerhagen P, Albrecht L, Costa FTM. "Transcriptomics of Plasmodium vivax cytoadherence within human host malaria infections: a dua perspective" at 7th International Conference on Plasmodium vivax Research (ICPvR), from 25th to 28th June 2019, Paris - FRANCE
INVITED SEMINAR - Bourgard C, "Mode of Action of Natural Products in Pathogenic Gram-negative bacteria and their development as antibacterial agents" and "Antimicrobial compound screening for Drug Discovery" at CARe Meeting, 2nd to 3rd June 2019, Gothenburg - SWEDEN
POSTER - Bourgard C, Lopes SCV, Lacerda MVG, Albrecht L, Costa FTM. “Plasmodium vivax rosetting & Human immunity: a transcriptomic approach to uncover host-pathogen interactions” at GBMeeting, from 28th to 30th January 2019, Campinas, São Paulo - BRAZIL
POSTER - Bittencourt NC, Leite JA, Silva ABIE, Pimenta TS, Silva-Filho JL, Cassiano GC, Lopes SCP, dos-Santos JCK, Bourgard C, Nakaya H, Ventura AMRS, Lacerda MVG, Ferreira MU, Machado RLD, Albrecht L and Costa FTM. “Genetic sequence characterization and naturally acquired immune response to Plasmodium vivax Rhoptry Neck Protein 2 (PvRON2)” at São Paulo School of Advanced Sciences on Vaccines, from 22nd November to 2nd December 2018, Santos, São Paulo - BRAZIL
POSTER - Bourgard C, Reymer A, Gao C, Ashok A, Deplace V, Barbier M, Cassiano GC, Witkowski B, Eriksson L, Grøtli M, Costa FTM, Bilsland E and Sunnerhagen P. “The neglected vivax malaria case: coupling target-based yeast system and in silico modelling for drug discovery” at 21st Century Drug Discovery and Development for Global Health, Keystone Symposia, from 17th to 20th October 2018, Berlin - GERMANY
PRESENTATION - Bourgard C, “Plasmodium vivax malaria”, 17th June 2018 at University of Georgia, GA-USA
POSTER - Bourgard C, Bilsland E, Costa FTM, Grøtl M, Witkowski B, Sunnerhagen P. “A chemical-genomic profiling approach for drug target discovery in Plasmodium vivax” at XIII BioMalPar Conference, from 29th to 31st May 2017, Heidelberg, GERMANY
POSTER - Bourgard C, Albrecht L, Lopes S, Lacerda MVG, Costa FTM. “Plasmodium vivax: molecular mechanisms involved in cytoadherence” at Science of Eradication: Malaria, from 22nd September to 2nd October 2015, São Paulo - BRAZIL
POSTER - Bourgard C, Albrecht L, Lopes S, Lacerda MVG, Costa FTM. “A reliable RNA preparation methodology suitable for Whole Transcriptome Shotgun Sequencing harvested from a single Plasmodium vivax-infected patient with scarce parasitemia” at XIV Reunião de Pesquisa em Malária from 30th September to 3rd October 2015, São Paulo - BRAZIL
POSTER - Bourgard C, Albrecht L, Lopes S, Lacerda MVG, Costa FTM. “Plasmodium vivax: molecular mechanisms involved in cytoadherence” at Evento Comemorativo de 20 Anos do Seminário Laveran & Deane, from 17th to 19th September 2015, Itacuruçá, Rio de Janeiro - BRAZIL
POSTER - Bourgard C, Albrecht L, Lopes S, Lacerda MVG, Costa FTM. “Reliable RNA isolation from enriched Plasmodium vivax field isolates for Whole Transcriptome Shotgun Sequencing” at The 5th International Conference of Research on Plasmodium vivax Malaria from 19th to 22nd May 2015, Denpasar, Bali - INDONESIA
PRESENTATION - Bourgard C, “Plasmodium vivax: molecular mechanisms involved in cytoadherence” at the XIX Seminar Laveran & Deane about Malaria from 1st to 5th September 2014, Itacuruçá, Rio de Janeiro - BRAZIL
PRESENTATION - Bourgard C, “Effects and implications of methylenetetrahydrofolate reductase (MTHFR) 677C>T (rs180113) and 1298A>C (rs1801131) genetic variants” at the I Conference about “Etiology and pathogenesis of venous thrombosis in the Portuguese population: interaction between clinic, laboratorial and molecular analysis”, May 2010, Lisbon- PORTUGAL
Bioinformatics & Functional Genomics Course (BIO210)
Lecture 2021 - 1. "OMICS for VACCINE DEVELOPMENT: THE MALARIA CASE"
2. "OMICS for DRUG DISCOVERY: THE MALARIA CASE"
Lecture 2020 - "OMICS for VACCINE DEVELOPMENT & DRUG DISCOVERY: THE MALARIA CASE
Eukaryotic Molecular Microbiology Course (BIO440)
Lecture 2021 - "Yeast Surrogate Genetics & in silico modelling for Target-based Antiplasmodial Drug Discovery"
Lecture 2020 - "Yeast Surrogate Genetics & in silico modelling for Target-based Antiplasmodial Drug Discovery"
Lecture 2019 - "Yeast Surrogate Genetics & in silico modelling for Target-based Antiplasmodial Drug Discovery"